Skip to main content
فهرست مقالات

Treadmill Running and Antioxidants Supplementation IncreasesCardiac Apelin and Oxidative Stress-related Biomarkers in Rats

نویسنده:

(8 صفحه - از 1 تا 8)

Purpose: The American Heart Association (AHA) published a statement on the importance of air pollution in the development of cardiovascular disease. Apelin is a multifunctional neuropeptide that plays an important regulatory role in cardiac dysfunction. We have investigated the cardioprotective effects of treadmill running and/or curcumin supplementation on the cardiac apelin and oxidative stress-related biomarkers such as total antioxidant capacity (TAC) and malondialdehyde (MDA) in male rats exposed to lead acetate. Material and Methods: In this study Forty male Wistar rats were randomly divided into 5 groups: (1) lead acetate; (2) curcumin; (3) treadmill running; (4) treadmill+ curcumin; and (5) sham-operate groups. The rats in groups 1 to 4 received lead acetate (20 mg/kg). Also, groups 3 and 4 underwent treadmill running, 15 to 22 m/min for 25 to 64 minutes, 5 times a week, for 8 weeks, while groups 2 and 4 received curcumin solution (30 mg/kg) intraperitoneally. Rats in group 5 only received curcumin solvent (ethyl oleat). Results: Lead administration resulted in a significant decrease in apelin, heart mass, TAC levels, and significantly increased MDA. Furthermore, treadmill running and\or curcumin supplementation resulted in a significant increase in apelin, heart mass, TAC levels and a significant decrease in MDA levels. Discussion and Conclusion: These results suggest a cardioprotective effect of antioxidants and regular endurance training in ameliorating lead-induced cardiotoxicity.

خلاصه ماشینی:

"Treadmill Running and Antioxidants Supplementation Increases Cardiac Apelin and Oxidative Stress-related Biomarkers in Rats Atena Yazdanshenas1, Valiollah Dabidi Roshan 2* 1Department of Exercise Physiology, college of Physical Education and Sport Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran 2 College of Physical Education and Sport Science, Department of Sport Physiology, University of Mazandaran, Babolsar, Iran Received 9 May 2013 Accepted 23 July 2013 Abstract Purpose: The American Heart Association (AHA) published a statement on the importance of air pollution in the development of cardiovascular disease. We have investigated the cardioprotective effects of treadmill running and/or curcumin supplementation on the cardiac apelin and oxidative stress-related biomarkers such as total antioxidant capacity (TAC) and malondialdehyde (MDA) in male rats exposed to lead acetate. Hence, the aim of the current study was to examine the effects of treadmill running and herbal supplementation of curcumin on left ventriclar apelin and oxidative stress-related biomarkers (MDA and TAC) in male rats exposed to lead acetate. Discussion and Conclusion We demonstrated that apelin levels are elevated in rats after treatment with curcumin and treadmill running by reversing oxidative stress-related biomarkers (MDA and TAC) by exposure to lead acetate. (2006) revealed that long-term swimming training reduced pathogenesis related to hypertension and reversed the down-regulation of Table 1: Effect of treadmill running and Curcumin on left ventriclar apelin, heart mass, TAC and MDA levels in rats during chronic exposure to lead acetate."


برای مشاهده محتوای مقاله لازم است وارد پایگاه شوید. در صورتی که عضو نیستید از قسمت عضویت اقدام فرمایید.