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Cadmium contamination of drinking water and its treatment using biological chelators مقاله

نویسنده:

چکیده:

Background: Cadmium (Cd) is an extremely toxic metal and environmental exposure to Cd has been particularly problematic in the world. Oral exposure to Cd may result in adverse effects on a number of tissues, the immune system, and the cardiovascular system. Compounds containing Cd are also carcinogenic. The presence of Cd in drinking water resources in the southeastern region of Rafsanjan plain (Iran) at concentrations greater than acceptable limits may result in various adverse health effects. The aim of this research was to test the chelation potency of deferasirox (DFS or ICL670), a tridentate metal chelator, and deferiprone (L1), a bidentate metal chelator, in the mobilization of Cd in Cd-exposed rats as a biological model. Materials and Methods: Male Wistar rats were exposed to 40 mg/kg body weight of cadmium chloride in drinking water for 6 weeks, followed by treatment with DFS (100 mg/kg body weight, oral, once daily) and L1 (100 mg/kg body weight, oral, once daily), alone or in combination, for 7 consecutive days. After chelation therapy, the rats were anesthetized by ether vapor and immobilized by cervical dislocation. Then, their heart, liver, kidneys, intestine, and blood were sampled for clinical hematological variables and determination of Cd and Fe concentration by inductively coupled plasma optical emission spectrometry (ICP-OES). The data were subjected to statistical analysis using Student’s t-test. All Ρ values of less than 0.05 were considered significant. Results: The results show that both chelators (DFS and L1) increase the removal of Cd from the tissues. No effects of Cd or any of the two treatments (L1 or DFS) were observed on white blood cell (WBC) count, red blood cell (RBC) count, and hemoglobin (Hb) level. Conclusions: The comparison of single and combined therapy showed that the combined chelation therapy (DFS + L1) was more effective in depleting Cd concentration in soft tissues.

خلاصه ماشینی:

"Materials and Methods: Male Wistar rats were exposed to 40 mg/kg body weight of cadmium chloride in drinking water for 6 weeks, followed by treatment with DFS (100 mg/kg body weight,oral, once daily) and L1 (100 mg/kg body weight, oral, once daily), alone or in combination, for 7 consecutive days. 7% of the residents of the study area had, respectively, been exposed to high levels of lead and Cd. The heavy metals, such as Cd, contamination of drinking water resources in Rafsanjan plain is linked to both natural presence of sulfide veins in this area and manmade pollution due to the presence of the main road and agricultural use of pesticides (4, 5). Table 1: Concentration of cadmium (mg/kg) in cadmium-intoxicated rats before and after chelation therapy (View the image of this page)Values are presented as mean ± SEM (n = 5); *Significant at Ρ < 0. 05 when compared with vehicle Cd Table 2: Concentration of iron (mg/kg) in cadmium-intoxicated rats before and after chelation therapy (View the image of this page)Values are presented as mean ± SEM (n = 5); *Significant at Ρ < 0. Table 3: Hematological variables in the blood of cadmium-intoxicated rats before and after chelation therapy (View the image of this page)WBC: White blood cell count as × 103/μl; RBC: Red blood cell count as × 106/μl; Hb: Hemoglobin as g/l; PLT: Platelet as × 103/μl; Values are presented as mean ± SEM (n = 5); *Significant at Ρ < 0."

کلیدواژه ها:

Rats ، Cadmium ، Drinking Water ، Chelation Therapy


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